Hippo signaling pathway transcription co-activator YAP is localized to podosomes/invadopodia in Src-transformed NIH-3T3 fibroblasts
نویسندگان
چکیده
منابع مشابه
Hippo/YAP signaling pathway is involved in osteosarcoma chemoresistance
BACKGROUND Osteosarcoma is the most common bone malignancy in children and adolescents, and 20%-30% of the patients suffer from poor prognosis because of individual chemoresistance. The Hippo/yes-associated protein (YAP) signaling pathway has been shown to play a role in tumor chemoresistance, but no previous report has focused on its involvement in osteosarcoma chemoresistance. This study aime...
متن کاملThe Hippo-YAP signaling pathway and contact inhibition of growth.
The Hippo-YAP pathway mediates the control of cell proliferation by contact inhibition as well as other attributes of the physical state of cells in tissues. Several mechanisms sense the spatial and physical organization of cells, and function through distinct upstream modules to stimulate Hippo-YAP signaling: adherens junction or cadherin-catenin complexes, epithelial polarity and tight juncti...
متن کاملMerlin and Angiomotin in Hippo-Yap Signaling
M. Oren and Y. Aylon (eds.), The Hippo Signaling Pathway and Cancer, DOI 10.1007/978-1-4614-6220-0_2, © Springer Science+Business Media New York 2013 Abstract Merlin, encoded by the NF2 tumor-suppressive gene, has been established through genetic studies in both Drosophila and mice as an important upstream regulator of the Hippo-Yap pathway. Recently, biochemical studies have identi fi ed Angio...
متن کاملHippo-YAP/TAZ signaling in angiogenesis
Angiogenesis is a complex, multistep process involving dynamic changes in endothelial cell (EC) shapes and behaviors, especially in specialized cell types such as tip cells (with active filopodial extensions), stalk cells (with less motility) and phalanx cells (with stable junction connections). The Hippo-Yes-associated protein (YAP)/ transcription activator with PDZ binding motif (TAZ) signali...
متن کاملHippo pathway effector Yap is an ovarian cancer oncogene.
The Hippo pathway regulates organ size and tumorigenesis in Drosophila and mammals and is altered in a variety of human cancers, yet it remains unclear if the Hippo pathway is of prognostic significance to cancer patients. Here we show that the key targets of Hippo signaling, transcriptional coactivators Yki and Yap, play a conserved role in promoting ovarian cancer in flies and humans, respect...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Matters (Zürich)
سال: 2016
ISSN: 2297-8240
DOI: 10.19185/matters.201602000035